"Factor XIIIa" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

Factor XIIIa Positive Control Slides , Product No. 251S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). Preparation Note Download the IFU specific to your product lot and format Note: This requires a keycode which can be found on your packaging or product label.

Piérard-Franchimont C, Piérard GE. Comment on J Cutan Pathol. 1998 Nov;25(10):553-8. Factor XIII, also known as fibrin-stabilizing factor, is a 320-kDa glycoprotein that is the proenzyme for plasma transglutaminase. In plasma, it circulates as a proenzyme consisting of two catalytic A subunits and two noncatalytic B subunits. Activated Factor XIII, Activated Factor 13, Coagulation Factor XIIIa, Coagulation Factor 13a, F13a, FXIIIa, FA13, Fibrin Stabilizing Factor, Fibrinoligase FSF (A subunit), FXIIIA, Protein Glutamine gamma Glutamyltransferase A chain, TGase, Transglutaminase A Chain Factor XIIIa is a dermal dendrocyte marker and shows variable reaction with these types of tumors (3,4). It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system (1-6). Factor XIIIa has also been used with CD34 to Define Factor xiiia.

Factor xiiia

Factor XIII or fibrin stabilizing factor is a zymogen found from the blood of humans and some other animals. It is activated by thrombin to factor XIIIa. XIIIa is an enzyme of the blood coagulation system that crosslinks fibrin. Deficiency of XIII worsens clot stability and increases bleeding tenden El factor de coagulación XIII, factor XIII, factor estabilizador de la fibrina o factor de Laki-Lorand es una proteína plasmática de síntesis hepática y plaquetaria, que participa en la ruta final común de la hemostasia, estabilizando el coágulo blando de fibrina o polímero de fibrina As you have mentioned in your e-mail, dendritic cells also express Factor XIIIa. However, the expressed levels of Factor XIIIa may be different from that in the placenta which usually shows very high levels of this protein.

Factor XIII is activated by thrombin in the presence of calcium which leads to the release of the activation peptide, followed by the dissociation of carrier subunits. The activated Factor XIII (XIIIa) acts on fibrin (Factor Ia) to form glutamyl-lysyl amide cross links between fibrin molecules leading to the formation of an insoluble clot.

Factor XIIIA is the catalytic subunit and is a dimer of M.W. 160,000. According to studies, Factor XIII is present in plasma as an alpha2beta2 heterodimer (M.W. 320,000); whereas in platelets, only the alpha2 unit exists.

Hämmare i koagulationssystemet Tissue factor TFPI VII VIIa XI XIa AT IX IXa HC-II VIII VIIIa Endothelial cell PCa X Xa PS XIII V Va PC IIa II XIIIa TM Fibrin

Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Factor XIIIa is a dermal dendrocyte marker and shows variable reaction with these types of tumors. It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system. Factor XIIIaは、血液凝固因子の一つで、真皮の間質の樹枝状細胞や紡錘形細胞の一部で陽性となる。皮膚科領域では、Dermatofibroma(DF)とDermatofibrosarcoma protuberans(DFSP)の鑑別に用いられる。 Factor XIII is activated by thrombin to form an active transglutaminase enzyme, factor XIIIa. Factor XIIIa introduces cross-links between fibrin-fibrin strands.

Genetics. Human factor XIII consist of A and B subunits. A subunit gene is F13A1. It is on the chromosome 6 at the Structure. Factor XIII of human blood is a Factor XIIIa (FXIIIa) (fibrinoligase, plasma transglutaminase, fibrin stabilizing factor, E.C. 2.3.2.13) is a glutaminyl-peptide γ-glutamyl transferase functioning in the final stages of the coagulation cascade, stabilizing the fibrin clot by crosslinking the α and γ chains of fibrin to form homopolymers (1-4). Factor XIIIa is a blood coagulation prototransglutaminase 1, which becomes an activated component of the final stages of the clotting cascade as a result of the interaction with thrombin and Ca 2+.
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The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map. The covalent stabilization of fibrin by thrombin-activated factor XIII (XIIIa) is the final event in the coagulation of blood. Plasma factor XIII (fibrin-stabilizing factor; FSF) zymogen consists of 2 "A" and 2 "B" subunits, the "A" subunits containing an active-center sulfydryl grouping mediating the transamidase activity of the enzyme.

Definition / general Fibrohistiocytic marker; note that peritumoral cells may also exhibit Factor XIIIa staining Also active form of factor XIII, an enzyme of coagulation system that crosslinks fibrin (Wikipedia: Factor XIII [Accessed 2 August 2018]) Stabilization of Fibrin The conversion of soluble fibrin to an insoluble fibrin clot is catalyzed by the transamidase factor XIIIa. Lysine and glutamine side chains of α- and γ-chains of fibrin are crosslinked to form homopolymers.
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Factor XIII or fibrin stabilizing factor is a zymogen found from the blood of humans and some other animals. It is activated by thrombin to factor XIIIa. XIIIa is an

Factor XIII of human blood is a Factor XIIIa (FXIIIa) (fibrinoligase, plasma transglutaminase, fibrin stabilizing factor, E.C. 2.3.2.13) is a glutaminyl-peptide γ-glutamyl transferase functioning in the final stages of the coagulation cascade, stabilizing the fibrin clot by crosslinking the α and γ chains of fibrin to form homopolymers (1-4). Factor XIIIa is a blood coagulation prototransglutaminase 1, which becomes an activated component of the final stages of the clotting cascade as a result of the interaction with thrombin and Ca 2+. Factor XIII (FXIII) is a key molecule in the field of blood coagulation and in the last decades it has weakened attention within the field of angiogenesis and tissue repair.

Tissue or cells. Specimen Preparation. Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen (cells must be prepared into a cellblock).

Tar man bort Externa vägen (något främmande kommer utifrån, tissue factor som kommer från vävnaden). PDGF = Platelet Derived Growth Factor Den är involverad i ateroskleros och kan Faktor XIIIa är ett transglutaminas och binder kovalent samman närliggande Vid sepsis frisätts cytokiner, till exempel tumor necrosis factor-α (TNF-α) Faktor XIIIa bildar starka bindningar mellan fibrinmolekyler så att ett Aktiv i hemostasen, syntetiserar: Tissue factor (TF) Prostacyclin vWF av faktor XIIIa stabiliserar pluggenKoagulationmodeller - IInre och yttre Hämmare i koagulationssystemet Tissue factor TFPI VII VIIa XI XIa AT IX IXa HC-II VIII VIIIa Endothelial cell PCa X Xa PS XIII V Va PC IIa II XIIIa TM Fibrin PDGF = Platelet Derived Growth Factor Den är involverad i ateroskleros och kan bidra stabiliseringgenom ett transglutaminas (faktor XIIIa) (S2-3).

Den aktiverade formen av faktor XIII, ett transglutaminas, som stabiliserar bildandet av den fibrinpolymer (blodkrusta) som utgör slutskedet i koagulationskaskaden. Engelsk definition 1. J Cutan Pathol.